BLZ945isaninhibitoroftheCSF-1Rkinasereceptor;itexhibitsimmunostimulatoryandanticancerchemotherapeuticactivitiesandpreventsskeletalmetastasisofdiseases.BLZ945preventsturnoveroftumor-associatedmacrophagesandincreasesCD8+Tcelllevels,limitingtumorgrowthinanimalmodelsofmammarycarcinogenesis.
| CasNo. | 953769-46-5 |
|---|---|
| Purity | ≥95% |
| Formula | C20H22N4O3S |
| FormulaWt. | 398.48 |
| IUPACName | 4-[(2-{[(1R,2R)-2-Hydroxycyclohexyl]amino}-1,3-benzothiazol-6-yl)oxy]-N-methyl-2-pyridinecarboxamide |
| Synonym | BLZ945 |
| Solubility | SolubleinDMSO.Slightlysolubleinethanol.Insolubleinwater. |
| Appearance | Paleyellowsolid. |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | B4796InfoSheetPDF |
|---|
KrauserJA,JinY,WallesM,etal.PhenotypicandmetabolicinvestigationofaCSF-1Rkinasereceptorinhibitor(BLZ945)anditspharmacologicallyactivemetabolite.Xenobiotica.2015Feb;45(2):107-23.PMID:25180976.
StrachanDC,RuffellB,OeiY,etal.CSF1Rinhibitiondelayscervicalandmammarytumorgrowthinmurinemodelsbyattenuatingtheturnoveroftumor-associatedmacrophagesandenhancinginfiltrationbyCD8+Tcells.Oncoimmunology.2013Dec1;2(12):e26968.PMID:24498562.
