Cabazitaxelisasemi-synthetictaxoidthatisaneffectiveantineplasticagentusedinthetreatmentofprostatecancerandbreastcancer.CabazitaxelisshowntodisruptthemicrotubularnetworkincellsthatexhibitP-glycoprotein(Pgp)mediateddrugresistance.ItspooraffinityforPgpmakesitamoreeffectivetherapeuticagentthandocetaxelincancercellsthatbecomeresistanttotaxaneclassofcancerdrugs.
| CasNo. | 183133-96-2 |
|---|---|
| Purity | ≥98% |
| Formula | C45H57NO14 |
| FormulaWt. | 835.94 |
| ChemicalName | 1-hydroxy-7,10-dimethoxy-9-oxo-5,20-epoxytax-11-ene-2,4,13-triyl4-acetate2-benzoate13-((2R,3S)-3-(((tertbutoxy)carbonyl)amino)-2-hydroxy-3-phenylpropanoate) |
| IUPACName | (2α,5β,7β,10β,13α)-4-Acetoxy-1-hydroxy-13-{[(2R,3S)-2-hydroxy-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)-3-phenylpropanoyl]oxy}-7,10-dimethoxy-9-oxo-5,20-epoxytax-11-en-2-ylbenzoate |
| Synonym | XPR-6258;TXD258;TaxoidXRP6258;RPR116258A,jevtana. |
| Solubility | SolubleinDMSO(~100mg/mL),ethanol(~50mg/mL).Sparinglysolubleinwater. |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | C002041InfoSheetPDF |
|---|
