Description
Cardiogenol C induces cardiomyogenic effects in pluripotent P19 embryonic carcinoma cells. Cardiogenol C also significantly increases atrial natriuretic factor and Nkx2.5 expression and induces expression of cardiac Nav1.5 channels in C2C12 skeletal myoblasts. In multipotent stem cells from murine hair follicles, Cardiogenol C has also been shown to induce transdifferentiation into cardiomyocyte-like cells.
References
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Skalova S, Svadlakova T, Qureshi WMS, et al. Induced pluripotent stem cells and their use in cardiac and neural regenerative medicine. Int J Mol Sci. 2015 Feb;16(2):4043-4067. PMID: 25689424.
Christ GJ, Saul JM, Furth ME, Andersson KE. The pharmacology of regenerative medicine. Pharmacol Rev. 2013 Jul;65(3):1091-1133. PMID: 23818131.
Yau W, Tang MK, Chen E, et al. Cardiogenol C can induce mouse hair bulge progenitor cells to transdifferentiate into cardiomyocyt-like cells. Proteome Sci. 2011;9:3. PMID: 21247432.