cGAMPisacyclicdinucleotidethatfunctionsasanendogenoussecondmessengerthatdetectscytosolicDNAandinducesSTING-dependentinterferontype1responses.cGAMPexhibitsimmunostimulatoryactivityandactsasanadjuvant.Thiscompoundenhancesadaptiveimmuneresponsesbyincreasingantigen-specificIgGlevelsinvivo.
| Purity | ≥98% |
|---|---|
| Formula | C20H24N10O13P2・Na2 |
| FormulaWt. | 718.37 |
| Synonym | cyclic(adenosinemonophosphate-guanosinemonophosphate);cyclicGMP-AMP;c-(GpAp);3",3"-cGAMP |
| Solubility | Solubleinwater. |
| Appearance | Crystallinesolid. |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | G0250InfoSheetPDF |
|---|
MaF,LiB,LiuSY,etal.PositivefeedbackregulationoftypeIIFNproductionbytheIFN-inducIBLeDNAsensorcGAS.JImmunol.2015Feb15;194(4):1545-54.PMID:25609843.
ŠkrnjugI,GuzmánCA,RueckertC.CyclicGMP-AMPdisplaysmucosaladjuvantactivityinmice.PLoSOne.2014Oct8;9(10):e110150.Erratumin:PLoSOne.2015;10(3):e0123605.Ruecker,Christine[correctedtoRueckert,Christine].PMID:25295996.
WuJ,SunL,ChenX,etal.CyclicGMP-AMPisanendogenoussecondmessengerininnateimmunesignalingbycytosolicDNA.Science.2013Feb15;339(6121):826-30.PMID:23258412.
![LKT/CGAMP DISODIUM [STING LIGAND]/G0250/100 µg](https://www.ebiomall.cn/images/lktlabs/G0250.png)
