Curvularinisamacrocycliclactonemetaboliteproducedinseveralfungi.InamodeloftransgenicDBA/1micecurvularinsignificantlyreducedtheexpressionofproinflammatorygenesinvolvedinthepathogenesisofcollagen-inducedarthritisandrheumatoidarthritis.InanotherstudyusinghumanepithelialalveolarcelllineA549/8asthemodel,curvularinwasshowntoinhibitthecytokine-mixture-inducedinducIBLe-nitric-oxide-synthasepromoteractivityinadose-dependentmanner.
| CasNo. | 10140-70-2 |
|---|---|
| Purity | ≥98% |
| Formula | C16H20O5 |
| FormulaWt. | 292.33 |
| ChemicalName | (4S)-11,13-Dihydroxy-4-methyl-4,5,6,7,8,9-hexahydro-2H-3-benzoxacyclododecine-2,10(1H)-dione |
| IUPACName | (4S)-11,13-Dihydroxy-4-methyl-4,5,6,7,8,9-hexahydro-2H-3-benzoxacyclododecine-2,10(1H)-dione |
| MeltingPoint | 203-205°C |
| Solubility | SolubleinDMSO,ethanol,methanolandDMF.Insolubleinwater. |
| Appearance | Whitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | C822706InfoSheetPDF |
|---|
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YaoY,HausdingM,ErkelG,etal.Sporogen,S14-95,andS-curvularin,threeinhibitorsofhumaninduciblenitric-oxidesynthaseexpressionisolatedfromfungi.MolPharmacol.2003Feb;63(2):383-391.PMID:12527810.
KumarCG,MongollaP,SujithaP,etal.MetaboliteprofilingandBIOLOGicalactivitiesofbioactivecompoundsproducedbyChrysosporiumlobatumstrainBK-3isolatedformKazirangaNationalPark,Assam,India.Springerplus.2013Dec;2(1):122.PMID:23565355.
