Description
Trehaloseisanaturalα-linkeddisaccharidecomposedofα-glucoseunitsthatisfoundinplants,animals,bacteria,andfungi.TrehalosehashighwaterretentioncapABIlitiesandcanbeusedtoformgelsorpreventdesiccation.Derivativesoftrehaloseexhibitanticancer,anti-metastatic,andneuromodulatoryactivities;theymayalsoinduceautophagyandmodulateactivityoftoll-likereceptors(TLRs).
References
WilliamsB,NjaciI,MoghaddamL,etal.TrehaloseAccumulationTriggersAutophagyduringPlantDesiccation.PLoSGenet.2015Dec3;11(12):e1005705.PMID:26633550.
JiangYL,LiSX,LiuYJ,etal.SynthesisandEvaluationofTrehalose-BasedCompoundsasNovelInhibitorsofCancerCellMigrationandInvasion.ChemBiolDrugDes.2015Nov;86(5):1017-29.PMID:25855371.
RodriguezLavadoJ,SestitoSE,CighettiR,etal.Trehalose-andglucose-derivedglycoamphiphiles:small-moleculeandnanoparticleToll-likereceptor4(TLR4)modulators.JMedChem.2014Nov13;57(21):9105-23.PMID:25268544.