Description
Evacetrapibisacholesterolestertransferprotein(CETP)inhibitorthatexhibitsanti-atheroscleroticactivity.Thiscompoundincreasescholesteroleffluxcapacity.EvacetrapibalsoincreaseslevelsofHDLandApoA1anddecreaseslevelsofLDLandApoB.
Evacetrapibisacholesterolestertransferprotein(CETP)inhibitorthatexhibitsanti-atheroscleroticactivity.Thiscompoundincreasescholesteroleffluxcapacity.EvacetrapibalsoincreaseslevelsofHDLandApoA1anddecreaseslevelsofLDLandApoB.
Purity | ≥98% |
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Formula | C31H36F6N6O2 |
FormulaWt. | 638.66 |
Synonym | LY2484595 |
Appearance | WhitePowder |
StoreTemp | -20°C |
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InfoSheet | E8401InfoSheetPDF |
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NichollsSJ,RuotoloG,BrewerHB,etal.CholesterolEffluxCapacityandPre-Beta-1HDLConcentrationsAreIncreasedinDyslipidemicPatientsTreatedWithEvacetrapib.JAmCollCardiol.2015Nov17;66(20):2201-10.PMID:26564598.
SuicoJG,WangMD,FriedrichS,etal.Effectsofthecholesterylestertransferproteininhibitorevacetrapibonlipoproteins,apolipoproteinsand24-hambulatorybloodpressureinhealthyadults.JPharmPharmacol.2014Nov;66(11):1576-85.PMID:24961753.
CaoG,BeyerTP,ZhangY,etal.Evacetrapibisanovel,potent,andselectiveinhibitorofcholesterylestertransferproteinthatelevatesHDLcholesterolwithoutinducingaldosteroneorincreasingbloodpressure.JLipidRes.2011Dec;52(12):2169-76.PMID:21957197.