Helvolicacidisawell-knownfungalmetabolitethatinhibitsproteinsynthesisthroughelongationfactorGonthebacterialribosome.IthasshowninvitroantitrypanosomalactivityagainstTrypanosomabruceibruceiGUTat3.1withIC50valueof5.08µg/mL.HelvolicacidhasalsobeenfoundtobeweaklycytotoxicagainstnormalhumandiploidfibroblastswithIC50valueof>100µg/mL.FurThermore,Helvolicacidhasshowntoexhibitstrongantibacterialactivitiesagainsttwogram-positivebacteria:B.subtilisandmethicillin-resistantStaphylococcusaureus.
| CasNo. | 29400-42-8 |
|---|---|
| Purity | ≥99% |
| Formula | C33H44O8 |
| FormulaWt. | 568.71 |
| ChemicalName | (2Z)-2-[(4S,5S,6S,8S,9S,10R,13R,14S,16S)-6,16-diacetyloxy-4,8,10,14-tetramethyl-3,7-dioxo-5,6,9,11,12,13,15,16-octahydro-4H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoicacid |
| IUPACName | (4α,5α,6β,8α,9β,13α,14β,16β,17E)-6,16-Diacetoxy-4,8,14-trimethyl-3,7-dioxo-18-norcholesta-1,17,24-trien-21-oicacid |
| Synonym | Fumigacin,NSC319943,BRN3230584 |
| Solubility | SolubleinDMSO,acetoneorchloroform.Insolubleinwater. |
| Appearance | WhitetoOff-Whitepowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | H174466InfoSheetPDF |
|---|
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JayanettiDR,YueQ,BillsGF,etal.HypocoprinsA-C:newsesquiterpenoidsfromthecoprophilousfungusHypocoprarostrata.JNatProd.2015Mar27;78(3):396-401.PMID:25549014.
RatnaweeraPB,WilliamsDE,deSilvaED,etal.Helvolicacid,anantibacterialnortriterpenoidfmorthefungalendophyte,Xylariasp.oforchidAnoectochilussetaceusendemictoSriLanka.Mycology.2014Mar;5(1):23-28.PMID:24772371.
