Indoximodisaninhibitorofindoleamine2,3dioxygenase,whichplaysaroleinimmuneregulation.IndoximodhasbeenfoundtoenhanceinflammatorycytokinesIL-1betaandIL-6expressioninhumancornealepithelialcellsexposedtoinactivatedA.fumigatusspores.Indoximodhasalsobeenfoundasametaboliteintomatoplantsexposedtofungiorbacteria.
| CasNo. | 110117-83-4 |
|---|---|
| Purity | ≥98% |
| Formula | C12H14N2O2 |
| FormulaWt. | 218.26 |
| Synonym | NLG-8189,1-Methyl-D-tryptophan, |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | I525138InfoSheetPDF |
|---|
SolimanHH,MintonSE,HanHS,etal.AphaseIstudyofindoximodinpatientswithadvancedmalignancies.Oncotarget.2016Apr19;7(16):22928-22938.PMID:27008709
JiangN,ZhaoG,LinJ,etal.Indoleamine2,3-dioxygenaseisinvolvedintheinflammationresponseofcornealepithelialcellstoaspergillusfumigatusinfections.PLoSOne.2015Sep11;10(9):e0137423.PMID:26361229
CamanesG,ScalschiL,VicedoB,etal.AnuntargetedglobalmetabolomicanalysisrevealsthebiochemicalchangesunderlyingbasalresistanceandpriminginSolanumlycopersicum,andidentifies1-methyltryptophanasametaboliteinvolvedinplantresponsestoBotrytiscinereaandPseudomonassyringae.PlantJ.2015Oct;84(1):125-139.PMID:26270176
