LB-100isaninhibitorofproteinphosphatase2A(PP2A)thatexhibitspro-angiogenicandanticanceractivities.LB-100increasesexpressionofVEGFandHIF-1α.Thiscompoundalsodecreasesgrowthofpancreaticcancercellsandenhancestheactivityofotherco-admiNISTeredchemotherapeuticsinvariouscancermodels.
| CasNo. | 1026680-07-8 |
|---|---|
| Purity | ≥98% |
| Formula | C13H20N2O4 |
| FormulaWt. | 268.31 |
| IUPACName | 3-[(4-Methyl-1-piperazinyl)carbonyl]-7-oxABIcyclo[2.2.1]heptane-2-carboxylicacid |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | L0400InfoSheetPDF |
|---|
BaiX,ZhiX,ZhangQ,etal.Inhibitionofproteinphosphatase2AsensitizespancreaticcancertochemotherapybyincreasingdrugperfusionviaHIF-1α-VEGFmediatedangiogenesis.CancerLett.2014Dec28;355(2):281-7.PMID:25304380.
BaiXL,ZhangQ,YeLY,etal.Inhibitionofproteinphosphatase2Aenhancescytotoxicityandaccessibilityofchemotherapeuticdrugstohepatocellularcarcinomas.MolCancerTher.2014Aug;13(8):2062-72.PMID:24867249.
