Description
Lercanidipineisadihydropyridinecalciumchannelblocker.Itsignificantlycounteredwallthickeningandluminalnarrowingonsmallsizedarteries.Thiscompoundandothersimilardihydropyridine-typeCa2+antagoNISTsexertprotectiveeffectonretinalthatincludereducedthicknessofretinaandofinnerplexiform,outernuclearandlayerofinnerandoutersegmentsplusouterlimitinglayer,andlossofganglionicneurons.LercanidipineconsistentlydecreasedMMP-9activityandreducedoxidativestressinhypertensivepatients.Lercanidipinetreatmentofspontaneouslyhypertensiverats(SHR)during6weekswasabletorevertthedeleteriouseffectsofhypertensiononcorticalbonedensityandonthenumberofTRAP+cellsinthetibiaofSHR.
References
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