LKT/NVP-LDE225/N859614/25 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/NVP-LDE225/N859614/25 mg

LKT/NVP-LDE225/N859614/25 mg

商品编号： N859614-25mg

品牌： lktlabs

市场价： ¥8820.00

美元价： 5292.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDN859614

CasNo.956697-53-3

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

NVP-LDE225isaninhibitorofSmothatpreventshedgehog(Hh)signaling;itexhibitsanticancerchemotherapeuticandanti-metastaticactivities.NVP-LDE225iscurrentlyapprovedforthetreatmentofbasalcellcarcinomabutisalsoinclinicaltrialsasapotentialtreatmentforothercancers.Inrenalcellcarcinomacells,NVP-LDE225inhibitscellularproliferation,migration,andinvasion;inanimalmodels,itincreasessurvivalratesanddecreasestumorgrowth.NVP-LDE225alsoinhibitscellviABIlityinprostatecancercells.Inanimalmodelsofprostatecancer,thiscompoundinhibitstheepithelial-to-mesenchymaltransition(EMT),inducesapoptosis,decreasestheexpressionofBcl-2,Bcl-xl,XIAP,andsurvivin,andincreasestheexpressionofBaxandBak;italsoinhibitstumorgrowth.SmoantagoNISTssuchasNVP-LDE225alsocausealopecia,likelyduetoalterationinhairfollicleembryology.

ProductInfo

CasNo.	956697-53-3
Purity	≥98%
Formula	C₂₆H₂₆F₃N₃O₃
FormulaWt.	485.51
Synonym	Erismodegib,Sonidegib,LDE225

ShippingandStorage

StoreTemp	-20°C
ShipTemp	Ambient

Downloads

InfoSheet	N859614InfoSheetPDF

References

FergusonJ,HannamS,ToholkaR,etal.HairLossandHedgehogInhibitors-AClassEffect?BrJDermatol.2014Dec18.[Epubaheadofprint].PMID:25523648.

D"AmatoC,RosaR,MarcianoR,etal.InhibitionofHedgehogsignallingbyNVP-LDE225(Erismodegib)interfereswithgrowthandinvasionofhumanrenalcellcarcinomacells.BrJCancer.2014Sep9;111(6):1168-79.PMID:25093491.

NantaR,KumarD,MeekerD,etal.NVP-LDE-225(Erismodegib)inhibitsepithelial-mesenchymaltransitionandhumanprostatecancerstemcellgrowthinNOD/SCIDIL2RγnullmicebyregulatingBmi-1andmicroRNA-128.Oncogenesis.2013Apr8;2:e42.PMID:23567619.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂