Oligomycin C is a fermentation product isolated from Streptomyces diastatochromogenes. Oligomycins are polyketides composed of macrocyclic lactones fused to bicyclic spiroketal ring systems. Oligomycin is known to inhibit F1F0-class ATPases.
| Cas No. | 11053-72-5 |
|---|---|
| Purity | ≥97% |
| Formula | C45H74O10 |
| Formula Wt. | 775.08 |
| Chemical Name | (1S,4E,5'R,6R,6'R,7S,8R,10S,11R,12R,14R,15R,16S,18E,20E,22S,25R,27S,28R,29S)-22-Ethyl-7,11,15-trihydroxy-6'-[(2S)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-3',4',5',6'-tetrahydro-3H,9H,13H- spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-pyran]-3,9,13-trione |
| Synonym | 12-Deoxyoligomycin A |
| Melting Point | 94-101°C |
| Solubility | Soluble in ethanol, methanol, DMF, and DMSO. Insoluble in water. |
| Appearance | White powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | O451328 Info Sheet PDF |
|---|
Salim AA, Tan L, Huang XC, et al. Oligomycins as inhibitors of K-Ras plasma membrane localisation. Org Biomol Chem. 2016 Jan 14;14(2):711-715. PMID: 26565618.
Harvey BJ. Energization of sodium absorption by the H(+)-ATPase pump in mitochondria-rich cells of frog skin. J Exp Biol. 1992 Nov;172:289-309. PMID: 1491227.
