LKT/PAC-1/P004080/5 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/PAC-1/P004080/5 mg

LKT/PAC-1/P004080/5 mg

商品编号： P004080-5mg

品牌： lktlabs

市场价： ¥980.00

美元价： 588.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDP004080

CasNo.315183-21-2

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

PAC-1(ProcaspaseActivatingCompound1)hasbeenidentifiedthroughhigh-throughputscreeningasacompoundthatmayenhancetheenzymaticactivityofprocaspase-3invitro.Procaspase-3maybeusefulasananticancerstrategyduetoitslowfrequencyofmutationsincancerandexpressionofitsenzymeinseveraltypesofcancers.PAC-1convertsprocaspase-3toactivecaspase-3invitrobychelatingzincionsandtherebyinducingcelldeathinthetumorcells.Inmultiplecancercelllines,PAC-1wasshowntotriggerendoplasmicreticulumstresssignalingandinduceautophagyandmitochondria-mediatedapotosis.

ProductInfo

CasNo.	315183-21-2
Purity	≥98%
Formula	C₂₃H₂₈N₄O₂
FormulaWt.	392.50
ChemicalName	N"-[(6-oxo-5-prop-2-enyl-1-cyclohexa-2,4-dienylidene)methyl]-2-[4-(phenylmethyl)-1-piperazinyl]acetohydrazide
IUPACName	N"-[(Z)-(3-Allyl-2-hydroxyphenyl)methylene]-2-(4-benzyl-1-piperazinyl)acetohydrazide
Synonym	(4-Benzylpiperazino)aceticacid(3-allyl-2-hyroxybenzylidene)hydrazide,1-Piperazineaceticacid,2-(phenylmethyl)-,[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hyrrazide

ShippingandStorage

StoreTemp	4°C
ShipTemp	Ambient

Downloads

InfoSheet	P004080InfoSheetPDF

References

SarkarA,BalakrishnanK,ChenJ,etal.MolecularevidenceofZnchelationoftheprocaspaseactivatingcompoundB-PAC-1inBcelllymphoma.Oncotarget.2016Jan19;7(3):3461-3476.PMID:26658105.

RothHS,HergenrotherPJ.Derivativesofprocaspase-activatingcompound1(PAC-1)andtheiranticanceractivities.CurrMedChem.2016;23(3):201-241.PMID:26630918.

SeerviM,SobhanPK,JosephJ,etal.ERO1alpha-dependentendoplasmicreticulum-mitochondrialcalciumfluxcontributestoERstressandmitochondrialpermeABIlizationbyprocaspase-activatingcompound-1(PAC-1).CellDeathDis.2013Dec19;4:e968.PMID:24357799.

LucasPW,SchmitJM,PetersonQP,etal.PharmacokineticsandderivationofananticancerdosingregimenforPAC-1,apreferentialsmallmoleculeactivatorofprocaspase-3,inhealthydogs.InvestNewDrugs.2011Oct;29(5):901-911.PMID:20499133.

PetersonQP,GoodeDR,WestDC,etal.PAC-1activatesprocaspase-3invitrothroughreliefofzinc-mediatedinhibition.JMolBiol.2009Apr24;388(1):144-158.PMID:19281821.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂