Reversineisapurineanalogthatreversesorinducesdifferentiation.Reversinedisplaysanticancerchemotherapeuticandanti-metastaticactivities;ittransformspreADIpocytesintomesenchymalstemcells,inducesautophagyinthyroidcancercells,anddownregulatesexpressionofmiR-133amiRNA.Thiscompoundinducesapoptosisandcelldeathinbreastcancercells.Inanimalmodelsofcancer,reversineinhibitsfocaladhesiondisassembly,decreasescellmotilityandinvasion,andpreventstumormetastasis.
| CasNo. | 656820-32-5 |
|---|---|
| Purity | ≥98% |
| Formula | C21H27N7O |
| FormulaWt. | 393.50 |
| IUPACName | N6-Cyclohexyl-N2-[4-(4-morpholinyl)phenyl]-3H-purine-2,6-diamine |
| ShipTemp | Ambient |
|---|
| InfoSheet | R1885InfoSheetPDF |
|---|
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KimM,YiSA,LeeH,etal.Reversineinducesmultipotencyoflineage-committedcellsthroughepigeneticsilencingofmiR-133a.BiochemBiophysResCommun.2014Feb28;445(1):255-62.PMID:24513286.
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