LKT/RITONAVIR/R3577/250 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/RITONAVIR/R3577/250 mg

LKT/RITONAVIR/R3577/250 mg

商品编号： R3577-250mg

品牌： lktlabs

市场价： ¥2480.00

美元价： 1488.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

ProductIDR3577

CasNo.155213-67-5

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

RitonavirisanHIVproteaseinhibitorthatiscommonlyusedasacomponentofhighlyactiveanti-retroviraltherapy(HAART)inthetreatmentofHIVinfection.Ritonavirexhibitsantiviral,anti-angiogenic,neuroprotective,andhyperlipidemicactivities.RitonavirinhibitsexpressionofVEGFandHIF-1α,decreasingproliferationinretinalepithelialcellsandindicatingpotentialuseasatreatmentforoculardiseases.Ritonaviralsoinhibitstranslocationofapoptosis-inducingfactor(AIF),activatescaspase9,andinhibitspermeABIlityalterationsinthemitochondrialmembranepotential,preventingapoptosisinretinalphotoreceptorcellsandmacrophages.Thiscompounddecreaseslevelsofsarco/endoplasmicreticulumCa2+-ATPase(SERCA)andintracellularCa2+,increasingendoplasmicreticularstressandinjury.Additionally,ritonavirincreaseslevelsofIL-6anddecreaseslevelsofADIponectin,GLUT4,andfattyacidsynthase,inhibitinglipogenesisandincreasinglipodystrophy;thiscompoundalsoincreaseslevelsofVLDL.

ProductInfo

CasNo.	155213-67-5
Purity	≥98%
Formula	C₃₇H₄₈N₆O₅S₂
FormulaWt.	720.95
IUPACName	1,3-thiazol-5-ylmethylN-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate
Synonym	Norvir
MeltingPoint	120-123°C
Solubility	DMSOto10mg/mL,Ethanolto3mg/mL,Methanol
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

InfoSheet	R3577InfoSheetPDF
Brochures	AntiviralsBooklet

References

VadlapatlaRK,VadlapudiAD,PalD,etal.RitonavirinhibitsHIF-1α-mediatedVEGFexpressioninretinalpigmentepithelialcellsinvitro.Eye(Lond).2013Nov8.[Epubaheadofprint].PMID:24202050.

KaoE,ShinoharaM,FengM,etal.HumanimmunodeficiencyvirusproteaseinhibitorsmodulateCa2+homeostasisandpotentiatealcoholicstressandinjuryinmiceandprimarymouseandhumanhepatocytes.Hepatology.2012Aug;56(2):594-604.PMID:22407670.

HisatomiT,NakazawaT,NodaK,etal.HIVproteaseinhibitorsprovideneuroprotectionthroughinhibitionofmitochondrialapoptosisinmice.JClinInvest.2008Jun;118(6):2025-38.PMID:18497877.

GrigemS,Fischer-PosovszkyP,DebatinKM,etal.TheeffectoftheHIVproteaseinhibitorritonavironproliferation,differentiation,lipogenesis,geneexpressionandapoptosisofhumanpreadipocytesandadipocytes.HormMetabRes.2005Oct;37(10):602-9.PMID:16278782.

RiddleTM,SchildmeyerNM,PhanC,etal.TheHIVproteaseinhibitorritonavirincreaseslipoproteinproductionandhasnoeffectonlipoproteinclearanceinmice.JLipidRes.2002Sep;43(9):1458-63.PMID:12235177.

BeachJW.Chemotherapeuticagentsforhumanimmunodeficiencyvirusinfection:mechanismofaction,pharmacokinetics,metabolism,andadversereactions.ClinTher.1998Jan-Feb;20(1):2-25.PMID:9522101.

KawakamiK,HaradaT,YoshihashiY,etal.Correlationbetweenglass-formingabilityandfragilityofpharmaceuticalcompounds.JPhysChemB.2015Apr9;119(14):4873-4880.PMID:25781503.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂