Ro 20-1724 is a phosphodiesterase inhibitor that has been shown to enhance cognition in streptozocin treated rats. In addition to learning and memory improvements, Ro 20-1724 was also found to attenuate oxidative stress and restore cholinergic functions. Furthermore, this inhibitor was also shown to produce a potent anti-inflammatory effect in a murine model.
| Cas No. | 29925-17-5 |
|---|---|
| Purity | ≥98% |
| Formula | C15H22N2O3 |
| Formula Wt. | 278.35 |
| Chemical Name | 4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone |
| IUPAC Name | 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone |
| Melting Point | 126-127°C |
| Solubility | Soluble in DMSO (200 mg/ml), ethanol (40 mg/ml). |
| Appearance | White powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | R5602 Info Sheet PDF |
|---|
Sharma V, Bala A, Deshmukh R, et al. Neuroprotective effect of Ro-20-1724 a phosphodiesterase4 inhibitor against intracerebroventricular streptozocin induced cognitive deficit and oxidative stress in rats. Pharmacol Biochem Behav. 2012 Apr; 101(2):239-245. PMID: 2285388.
Clayton R, Dick C, Mackenzie A, et al. The effect of selective phosphodiesterase inhibitors, alone and in combination, on a murine model of allergic asthma. Respir Res. 2004 May 5; 5(1):4. PMID: 15169552.
