SAGisaSmoothened(Smo)agoNISTprimarilyusedinresearchmodelstostudyHedgehogsignalingpathways.Invitro,SAGstimulatesosteoblasticdifferentiationofmesenchymalstemcellsandenhancesproliferationofpulmonaryarterialsmoothmusclecells.SAGalsoincreasesexpressionofPatchedandeffluxofcholesterol.Invivo,thiscompoundexhibitsneuroprotectiveactivity,preventingglucocorticoid-inducedneurotoxicity.
| Purity | ≥98% |
|---|---|
| FormulaWt. | 617.02 |
| Solubility | SolubleinwaterorDMSO. |
| Appearance | Lightyellowsolid. |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | S0225InfoSheetPDF |
|---|
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