Description
Tedizolid is a second-generation oxazolidinone found to be effective against gram-positive pathogens. In murine models of penicillin-resistant Streptococcus pneumoniae infection, tedizolid was as effective as or more effective than linezolid and showed less inflammatory cell invasion into alveolar spaces. In another study on a murine model of hematogenous pulmonary infection, tedizolid and linezolid both showed antimicrobial and immunomodulatory results superior to treatment with vancomycin.
References
Choi S, Im W, Bartizal K. Activity of tedizolid phosphate (TR-701) in murine models of infection with penicillin-resistant and penicillin-sensitive Streptococcus pneumoniae. Antimicrob Agents Chemother. 2012 Sep;56(9):4713-4717. PMID: 22713339.
Kaku N, Morinaga Y, Takeda K, et al. Antimicrobial and immunomodulatory effects of tedizolid against methicillin-resistant Staphylococcus aureus in a murine model of hematogenous pulmonary infection. Int J Med Microbiol. 2016 Sep;306(6):421-428. PMID: 27259840.
Park KH, Greenwood-Quaintance KE, Mandrekar J, et al. Activity of tedizolid in methicillin-resistant Staphylococcus aureus experimental foreign body-associated osteomyelitis. Antimicrob Agents Chemother. 2016 Oct 21;60(11):6568-6572. PMID: 27550347.
