Tedizolidisasecond-generationoxazolidinonefoundtobeeffectiveagainstgram-positivepathogens.Inmurinemodelsofpenicillin-resistantStreptococcuspneumoniaeinfection,tedizolidwasaseffectiveasormoreeffectivethanlinezolidandshowedlessinflammatorycellinvasionintoalveolarspaces.Inanotherstudyonamurinemodelofhematogenouspulmonaryinfection,tedizolidandlinezolidbothshowedantimicrobialandimmunomodulatoryresultssuperiortotreatmentwithvancomycin.
| CasNo. | 856866-72-3 |
|---|---|
| Purity | ≥98% |
| Formula | C17H15FN6O3 |
| FormulaWt. | 370.34 |
| ChemicalName | 3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one |
| IUPACName | (5R)-3-{3-Fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl}-5-(hydroxymethyl)-1,3-oxazolidin-2-one |
| Synonym | TR700 |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | BlueIce |
| InfoSheet | T165131InfoSheetPDF |
|---|
ChoiS,ImW,BartizalK.Activityoftedizolidphosphate(TR-701)inmurinemodelsofinfectionwithpenicillin-resistantandpenicillin-sensitiveStreptococcuspneumoniae.AntimicrobAgentsChemother.2012Sep;56(9):4713-4717.PMID:22713339.
KakuN,MorinagaY,TakedaK,etal.Antimicrobialandimmunomodulatoryeffectsoftedizolidagainstmethicillin-resistantStaphylococcusaureusinamurinemodelofhematogenouspulmonaryinfection.IntJMedMicrobiol.2016Sep;306(6):421-428.PMID:27259840.
ParkKH,Greenwood-QuaintanceKE,MandrekarJ,etal.Activityoftedizolidinmethicillin-resistantStaphylococcusaureusexperimentalforeignbody-associatedosteomyelitis.AntimicrobAgentsChemother.2016Oct21;60(11):6568-6572.PMID:27550347.
