Tedizolidisasecond-generationoxazolidinonefoundtobeeffectiveagainstgram-positivepathogens.Inmurinemodelsofpenicillin-resistantStreptococcuspneumoniaeinfection,tedizolidwasaseffectiveasormoreeffectivethanlinezolidandshowedlessinflammatorycellinvasionintoalveolarspaces.Inanotherstudyonamurinemodelofhematogenouspulmonaryinfection,tedizolidandlinezolidbothshowedantimicrobialandimmunomodulatoryresultssuperiortotreatmentwithvancomycin.
| CasNo. | 856867-55-5 |
|---|---|
| Purity | ≥98% |
| Formula | C17H16FN6O6P |
| FormulaWt. | 450.32 |
| ChemicalName | (R)-(3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyldihydrogenphosphate |
| IUPACName | [(5R)-3-[3-fluoro-4-[6-(2-methyltetrazol-5-yl)pyridin-3-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyldihydrogenphosphate |
| Synonym | DA7218;Sivextro;TR701 |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | T165133InfoSheetPDF |
|---|
ChoiS,ImW,BartizalK.Activityoftedizolidphosphate(TR-701)inmurinemodelsofinfectionwithpenicillin-resistantandpenicillin-sensitiveStreptococcuspneumoniae.AntimicrobAgentsChemother.2012Sep;56(9):4713-4717.PMID:22713339.
KakuN,MorinagaY,TakedaK,etal.Antimicrobialandimmunomodulatoryeffectsoftedizolidagainstmethicillin-resistantStaphylococcusaureusinamurinemodelofhematogenouspulmonaryinfection.IntJMedMicrobiol.2016Sep;306(6):421-428.PMID:27259840.
ParkKH,Greenwood-QuaintanceKE,MandrekarJ,etal.Activityoftedizolidinmethicillin-resistantStaphylococcusaureusexperimentalforeignbody-associatedosteomyelitis.AntimicrobAgentsChemother.2016Oct21;60(11):6568-6572.PMID:27550347.
