Torin1isatricyclicbenzonaphthyridinonethatinhibitsmTORC1/2andexhibitsanti-inflammatory,anti-angiogenic,anti-metastatic,andanticancerchemotherapeuticactivities.Inmacrophages,torin1decreasescytokineproductionandinflammatoryresponsesignaling.Incolorectalcancercells,thiscompoundinducesapoptosisandinhibitsgrowth,motility,invasiveness,andsurvival;italsoinhibitstumorgrowthandvesselformationinvivo.
| CasNo. | 1222998-36-8 |
|---|---|
| Purity | ≥98% |
| Formula | C35H28F3N5O2 |
| FormulaWt. | 607.64 |
| IUPACName | 1-[4-(4-Propionyl-1-piperazinyl)-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h][1,6]naphthyridin-2(1H)-one |
| InfoSheet | T5870InfoSheetPDF |
|---|
ShappleyRK,SpentzasT.DifferentialRoleofRapamycinandTorin/KU63794inInflammatoryResponseof264.7RAWMacrophagesStimulatedbyCA-MRSA.IntJInflam.2014;2014:560790.PMID:24800098.
FrancipaneMG,LagasseE.Selectivetargetingofhumancoloncancerstem-likecellsbythemTORinhibitorTorin-1.Oncotarget.2013Nov;4(11):1948-62.PMID:24185040.
LiuQ,ChangJW,WangJ,etal.Discoveryof1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-oneasahighlypotent,selectivemammaliantargetofrapamycin(mTOR)inhibitorforthetreatmentofcancer.JMedChem.2010Oct14;53(19):7146-55.PMID:20860370.
