Torin2isatricyclicbenzonaphthyridinonethatinhibitsmTORC1/2andexhibitsanticanceractivity.Inhepatocellularcarcinomacells,torin2inhibitscellgrowthandsurvivalandinducesapoptosisandautophagy.Inacutelymphoblasticleukemia(ALL)cells,torin2inducesG0/G1phasecellcyclearrestandinhibitscellgrowth.
| CasNo. | 1223001-51-1 |
|---|---|
| Purity | ≥98% |
| Formula | C24H15F3N4O |
| FormulaWt. | 432.41 |
| IUPACName | 9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2(1H)-one |
| InfoSheet | T5871InfoSheetPDF |
|---|
WangC,WangX,SuZ,etal.ThenovelmTORinhibitorTorin-2inducesautophagyanddownregulatestheexpressionofUHRF1tosuppresshepatocarcinomacellgrowth.OncolRep.2015Oct;34(4):1708-16.PMID:26239364.
SimioniC,CaniA,MartelliAM,etal.ActivityofthenovelmTORinhibitorTorin-2inB-precursoracutelymphoblasticleukemiaanditstherapeuticpotentialtopreventAktreactivation.Oncotarget.2014Oct30;5(20):10034-47.PMID:25296981.
