AG-1517isaninhibitorofEGFRthatdisplaysanticancerproperties.Invitro,thiscompoundinhibitsgrowthofcholangiocarcinomacells.Inkeratinocytes,AG-1517suppressesDNAreplication,cellcycleprogression,andcellproliferation,exhibitingpotentialbenefitinthetreatmentofpsoriasis.
| CasNo. | 153436-54-5 |
|---|---|
| Purity | ≥98% |
| Formula | C16H14BrN3O2 |
| FormulaWt. | 360.21 |
| IUPACName | N-(3-Bromophenyl)-6,7-dimethoxy-4-quinazolinamine |
| Synonym | TyrphostinAG1517;PD153035;SU5271 |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | A2501InfoSheetPDF |
|---|
ZhangZ,OyesanyaRA,CampbellDJ,etal.Preclinicalassessmentofsimultaneoustargetingofepidermalgrowthfactorreceptor(ErbB1)andErbB2asastrategyforcholangiocarcinomatherapy.Hepatology.2010Sep;52(3):975-86.PMID:20607690.
PowellTJ,Ben-BassatH,KleinBY,etal.Growthinhibitionofpsoriatickeratinocytesbyquinazolinetyrosinekinaseinhibitors.BrJDermatol.1999Nov;141(5):802-10.PMID:10583160.
