Description
AG-18isatyrphostinthatinhibitsEGFRandPDGFR;italsoblocksCa2+currentsinvascularsmoothmuscle.AG-18suppressesclathrin-mediatedendocytosisandisoftenusedtostudythatprocess.
AG-18isatyrphostinthatinhibitsEGFRandPDGFR;italsoblocksCa2+currentsinvascularsmoothmuscle.AG-18suppressesclathrin-mediatedendocytosisandisoftenusedtostudythatprocess.
CasNo. | 118409-57-7 |
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Purity | ≥98% |
Formula | C10H6N2O2 |
FormulaWt. | 186.17 |
IUPACName | (3,4-Dihydroxybenzylidene)malononitrile |
Synonym | TyrphostinA23 |
StoreTemp | -20°C |
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ShipTemp | Ambient |
InfoSheet | A2401InfoSheetPDF |
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MontezanoAC,CalleraGE,YogiA,etal.AldosteroneandangiotensinIIsynergisticallystimulatemigrationinvascularsmoothmusclecellsthroughc-Src-regulatedredox-sensitiveRhoApathways.ArteriosclerThrombVascBiol.2008Aug;28(8):1511-8.PMID:18467645.
YaishP,GazitA,GilonC,etal.BlockingofEGF-dependentcellproliferationbyEGFreceptorkinaseinhibitors.Science.1988Nov11;242(4880):933-5.PMID:3263702.