Description
Alternariol9-methylether(A9ME)isahighlytoxicmutagenicphytotoxininitiallyproducedbyspeciesofAlternaria.A9MEispresentingrainandfruitusedforlivestockfeedandhumanconsumption.A9MEinhibitstheelectrontransportchain,preventingphotosynthesisinvitro.Additionally,A9MEmayexhibitanticancerpotentialinacellularmodelofcoloncarcinoma,asitdecreasesthemitochondrialmembranepotential,increasingreleaseofcytochromecandactivatingcaspases3and9;thisresultsinapoptosisandcelldeath.
References
DemunerAJ,BarbosaLC,MirandaAC,etal.TheFungalPhytotoxinAlternariol9-MethylEtherandSomeofItsSyntheticAnaloguesInhibitthePhotosyntheticElectronTransportChain.JNatProd.2013Nov18.[Epubaheadofprint].PMID:24245962.
BroggiL,ReynosoC,ResnikS,etal.OccurrenceofalternariolandalternariolmonomethyletherinbeveragesfromtheEntreRiosProvincemarket,Argentina.MycotoxinRes.2013Feb;29(1):17-22.PMID:23334721.
ScottPM,ZhaoW,FengS,etal.AlternariatoxinsalternariolandalternariolmonomethyletheringrainfoodsinCanada.MycotoxinRes.2012Nov;28(4):261-6.PMID:23087499.
BensassiF,GallerneC,elDeinOS,etal.MechanismofAlternariolmonomethylether-inducedmitochondrialapoptosisinhumancoloncarcinomacells.Toxicology.2011Dec18;290(2-3):230-40.PMID:22001388.