Alyssin is a sulfinyl analog of sulforaphane, an isothiocyanate (ITC). Alyssin exhibits antioxidative and anticancer activity. This compound inhibits the growth of colon cancer cells in vitro and induces phase II enzymes, increasing Nrf2 activity. Alyssin also decreases enzymatic metabolism of polycyclic aromatic hydrocarbons (PAHs), decreasing carcinogenic risk and displaying potential chemopreventive benefit.
| Cas No. | 646-23-1 |
|---|---|
| Purity | ≥97% |
| Formula | C7H13NOS2 |
| Formula Wt. | 191.32 |
| Chemical Name | 1-Isothiocyanato-5-(methylsulfinyl)pentane; |
| IUPAC Name | 1-isothiocyanato-5-methylsulfinylpentane |
| Synonym | 5-methylsulfinylpentyl isothiocyanate |
| Solubility | Soluble in water, DMSO, ethanol, or chloroform. |
| Appearance | Slightly yellowish liquid |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | A4496 Info Sheet PDF |
|---|
Lubelska K, Misiewicz-Krzemińska I, Milczarek M, et al. Isothiocyanate-drug interactions in the human adenocarcinoma cell line Caco-2. Mol Cell Biochem. 2012 Aug;367(1-2):19-29. PMID: 22527941.
Kim MJ, Kim SH, Lim SJ. Comparison of the apoptosis-inducing capability of sulforaphane analogues in human colon cancer cells. Anticancer Res. 2010 Sep;30(9):3611-9. PMID: 20944144.
Skupinska K, Misiewicz-Krzeminska I, Stypulkowski R, et al. Sulforaphane and its analogues inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene. J Biochem Mol Toxicol. 2009 Jan-Feb;23(1):18-28. PMID: 19202560.
