Anastrozoleisathirdgenerationaromataseinhibitorthatsuppressessynthesisofestrogen.AnastrozoleexhibitsanticancerchemotherapeuticactivityandisclinicallyusedtotreatER-positivebreastcancer.Invitro,anastrozoleinhibitsproliferationofcancercellsbydisruptingthemitochondrialmembranepotentialandinducingapoptosis.Becauseofitsanti-estrogenproperties,anastrozolemaydecreasebonemineraldensityandincreasefracturerisk.
| CasNo. | 120511-73-1 |
|---|---|
| Purity | ≥99% |
| Formula | C17H19N5 |
| FormulaWt. | 293.37 |
| ChemicalName | 2,2"-(5-(IH-1,2,4-triazol-1-ylmethyl)-1,3-phenylene)bis(2-methylpropiononitrile) |
| IUPACName | 2-[3-(2-cyanopropan-2-yl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile |
| Synonym | ZD1033Pure,ZenecaZD1033 |
| MeltingPoint | 81-84°C |
| Solubility | solubleinmethanol,acetone,ethanol(59mg/mL),THF,ethylacetate,chloroform,DMSO(40mg/mL).Slightlysolubleinwater. |
| Appearance | WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | A5302InfoSheetPDF |
|---|
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McCloskeyE.Effectsofthird-generationaromataseinhibitorsonbone.EurJCancer.2006May;42(8):1044-51.PMID:16554149.
XanthopoulosJM,RomanoAE,MajumdarSK.ResponseofMouseBreastCancerCellstoAnastrozole,Tamoxifen,andtheCombination.JBiomedBiotechnol.2005;2005(1):10-19.PMID:15689634.
