Aprepitantisaninhibitorofthetachykinin/neurokinin1(NK1)receptorthatactsasanantiemeticoranti-nauseamedicine.Aprepitantalsoexhibitssomeanticancerchemotherapeuticandanti-angiogenicbenefitthroughitsinhibitionofNK1receptors,preventingbindingofsubstancePandinhibitingsubstanceP’sproliferativeandpro-angiogenicsignalingcascade.Thiscompoundmayalsodisplaysomeantidepressantactivity,althoughinvivoandclinicalresultshavebeenmixed.
| CasNo. | 170729-80-3 |
|---|---|
| Purity | ≥98% |
| Formula | C23H21F7N4O3 |
| FormulaWt. | 534.43 |
| ChemicalName | 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one |
| IUPACName | 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one |
| Synonym | (2R)-[(1R)-3,5-bis(trifluoromethyl)phenylethoxy]-(3S)-(4-fluoro)phenyl-4-(3-oxo-1,2,4-triazol-5-yl)methylmorpholine |
| MeltingPoint | 255°C |
| Appearance | Whitetooffwhitecrystallinepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | A6368MSDSPDF |
|---|---|
| InfoSheet | A6368InfoSheetPDF |
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MassaroAM,LenzKL.Aprepitant:anovelantiemeticforchemotherapy-inducednauseaandvomiting.AnnPharmacother.2005Jan;39(1):77-85.PMID:15562136.
KramerMS,CutlerN,FeighnerJ,etal.DistinctmechanismforantidepressantactivitybyblockadeofcentralsubstancePreceptors.Science.1998Sep11;281(5383):1640-5.PMID:9733503.
