ArenobufaginisabufanolidesteroidfoundintheArgentinetoadBufoarenarum.Thiscompoundexhibitsanticancerchemotherapeuticandanti-angiogenicproperties,butisalsocardiotoxic,inhibitingcardiovascularNa+/K+pumps.Incellularmodels,arenobufagininducesautophagyandapoptosis,inhibitingtumorgrowththroughindirectinhibitionofthePI3K/Akt/mTORsignalingpathway.ArenobufaginalsoinhibitsVEGFR2directlythroughblockadeofATP-bindingsites.
| CasNo. | 464-74-4 |
|---|---|
| Purity | ≥98% |
| Formula | C24H32O6 |
| FormulaWt. | 416.51 |
| IUPACName | 5-[(3S,5R,8R,9S,10S,11S,13R,14S,17R)-3,11,14-trihydroxy-10,13-dimethyl-12-oxo-2,3,4,5,6,7,8,9,11,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pyran-2-one |
| Appearance | WhiteCrystalPowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | A6818InfoSheetPDF |
|---|
ZhangDM,LiuJS,DengLJ,etal.Arenobufagin,anaturalbufADIenolidefromtoadvenom,inducesapoptosisandautophagyinhumanhepatocellularcarcinomacellsthroughinhibitionofPI3K/Akt/mTORpathway.Carcinogenesis.2013Jun;34(6):1331-42.PMID:23393227.
LiM,WuS,LiuZ,etal.Arenobufagin,abufadienolidecompoundfromtoadvenom,inhibitsVEGF-mediatedangiogenesisthroughsuppressionofVEGFR-2signalingpathway.BiochemPharmacol.2012May1;83(9):1251-60.PMID:22305746.
CruzJdosS,MatsudaH.Arenobufagin,acompoundintoadvenom,blocksNa(+)-K+pumpcurrentincardiacmyocytes.EurJPharmacol.1993Aug3;239(1-3):223-6.PMID:8223897.
GarraffoHM,GrosEG.Biosynthesisofbufadienolidesintoads.VI.Experimentswith[1,2-3H]cholesterol,[21-14C]coprostanol,and5beta-[21-14C]pregnanoloneinthetoadBufoarenarum.Steroids.1986Sep-Oct;48(3-4):251-7.PMID:3127947.
