AristolochicacidAisacarcinogeniccompoundfoundinAristolochiaandRADIxthathascommonlybeenusedintraditionalChinesemedicine.ThiscompoundinhibitsphospholipaseA2(PLA2)anddecreasesGABA-inducedreleaseofarachidonicacidandphosphatidylcholineaswellasexocytosisinvitro.
| CasNo. | 313-67-7 |
|---|---|
| Purity | ≥95% |
| Formula | C17H11NO7 |
| FormulaWt. | 341.27 |
| ChemicalName | 8-Methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1-carboxylicacid |
| IUPACName | 8-methoxy-6-nitronaphtho[2,1-g][1,3]benzodioxole-5-carboxylicacid |
| Synonym | Aristolochicacid;AristolochinBirthwort;Tardolyt |
| MeltingPoint | 281-286°C(dec.) |
| Solubility | SolubleinDMSOorethanol. |
| Appearance | YellowPowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | A6932MSDSPDF |
|---|---|
| InfoSheet | A6932InfoSheetPDF |
ChenWY,NiY,PanYM,etal.GABA,progesteroneandzonapellucidaactivationofPLA2andregulationbyMEK-ERK1/2duringacrosomalexocytosisinguineapigspermatozoa.FEBSLett.2005Aug29;579(21):4692-700.PMID:16098515.
StiborováM,FreiE,SopkoB,etal.Humancytosolicenzymesinvolvedinthemetabolicactivationofcarcinogenicaristolochicacid:evidenceforreductiveactivationbyhumanNAD(P)H:quinoneoxidoreductase.Carcinogenesis.2003Oct;24(10):1695-703.PMID:12869422.
