Triamcinolone is a synthetic steroid that downregulates expression of VEGF and exhibits anti-inflammatory and anti-angiogenic activities; it is an agonist at glucocorticoid receptors. Triamcinolone is clinically used to treat retinal edema and other ocular pathologies and may cause ocular hypertension.
| Cas No. | 124-94-7 |
|---|---|
| Purity | ≥98% |
| Formula | C21H27FO6 |
| Formula Wt. | 394.43 |
| Chemical Name | (11β,16α)-9-Fluoro-11,16,17,21-tetrahydroxy- pregna-1,4-diene-3,20-dione |
| IUPAC Name | (8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one |
| Synonym | Aristocort; Kenacort; Ledercort; Omiclon; Volon; Tricortale |
| Melting Point | 269-271°C |
| Solubility | Slightly soluble in water. |
| Appearance | White or Almost White Crystalline Powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | T7032 Info Sheet PDF |
|---|
Zhou H, Yang L, Li H, et al. Downregulation of VEGF mRNA expression by triamcinolone acetonide acetate-loaded chitosan derivative nanoparticles in human retinal pigment epithelial cells. Int J Nanomedicine. 2012;7:4649-60. PMID: 22942646.
McAllister IL, Vijayasekaran S, Chen SD, et al. Effect of triamcinolone acetonide on vascular endothelial growth factor and occludin levels in branch retinal vein occlusion. Am J Ophthalmol. 2009 May;147(5):838-46, 846.e1-2. PMID: 19211093.
Mizuno D, Matsubara A, Ogura Y. Effect of posterior sub-tenon administration of triamcinolone acetonide on leukocyte dynamics in rat retinal microcirculation after panretinal photocoagulation. Invest Ophthalmol Vis Sci. 2008 May;49(5):2127-33. PMID: 18436845.
