TriamcinoloneisasyntheticsteroidthatdownregulatesexpressionofVEGFandexhibitsanti-inflammatoryandanti-angiogenicactivities;itisanagoNISTatglucocorticoidreceptors.Triamcinoloneisclinicallyusedtotreatretinaledemaandotherocularpathologiesandmaycauseocularhypertension.
| CasNo. | 124-94-7 |
|---|---|
| Purity | ≥98% |
| Formula | C21H27FO6 |
| FormulaWt. | 394.43 |
| ChemicalName | (11β,16α)-9-Fluoro-11,16,17,21-tetrahydroxy-pregna-1,4-diene-3,20-dione |
| IUPACName | (8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one |
| Synonym | Aristocort;Kenacort;Ledercort;Omiclon;Volon;Tricortale |
| MeltingPoint | 269-271°C |
| Solubility | Slightlysolubleinwater. |
| Appearance | WhiteorAlmostWhiteCrystallinePowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | T7032InfoSheetPDF |
|---|
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McAllisterIL,VijayasekaranS,ChenSD,etal.Effectoftriamcinoloneacetonideonvascularendothelialgrowthfactorandoccludinlevelsinbranchretinalveinocclusion.AmJOphthalmol.2009May;147(5):838-46,846.e1-2.PMID:19211093.
MizunoD,MatsubaraA,OguraY.Effectofposteriorsub-tenonadministrationoftriamcinoloneacetonideonleukocytedynamicsinratretinalmicrocirculationafterpanretinalphotocoagulation.InvestOphthalmolVisSci.2008May;49(5):2127-33.PMID:18436845.
