Trichostatin A is an inhibitor of class I and II HDACs that exhibits anticancer and immunomodulatory activities. Trichostatin A induces cell cycle arrest, increases phosphorylation of JNK, downregulates activity of MCM-2, induces apoptosis, and inhibits proliferation of colon cancer cells. Trichostatin A also enhances differentiation and activity of CD4+ Foxp3+ Treg cells. Additionally, trichostatin A alters mammalian RNA splicing. Trichostatin A also alters RNA splicing.
| Cas No. | 58880-19-6 |
|---|---|
| Purity | ≥98% |
| Formula | C17H22N2O3 |
| Formula Wt. | 302.37 |
| Chemical Name | [R-(E,E)[-7-[4-(Dimethylamino)phenyl]-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide |
| IUPAC Name | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide |
| Synonym | TSA |
| Melting Point | 150-151°C |
| Solubility | Soluble in lower alchols. Slightly soluble in chloroform, ethyl acetate, acetone and benzene. |
| Appearance | Beige Powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Blue Ice |
| Info Sheet | T6933 Info Sheet PDF |
|---|---|
| Brochures | Epigenetic Modifiers Booklet |
Liu Y, He G, Wang Y, et al. MCM-2 is a therapeutic target of Trichostatin A in colon cancer cells. Toxicol Lett. 2013 Jul 31;221(1):23-30. PMID: 23770000.
Doñas C, Fritz M, Manríquez V, et al. Trichostatin A promotes the generation and suppressive functions of regulatory T cells. Clin Dev Immunol. 2013;2013:679804. PMID: 23737814.
Cecconi D, Donadelli M, Rinalducci S,et al. Proteomic analysis of pancreatic endocrine tumor cell lines treated with the histone deacetylase inhibitor trichostatin A. Proteomics. 2007 May;7(10):1644-53. PMID: 17443844.
