Tubacinisahistonedeacetylase6(HDAC6)inhibitorthatpreventsα-tubulindeacetylationanddisplaysanticanceractivity.Incellularmodelsofmultiplemyelomaandacutelymphoblasticleukemia,inhibitionofHDAC6inhibitscellmotilityandinducesaccumulationofubiquitinatedproteins,inducingapoptosis.Tubacin’sinhibitoryactiononHDACalsodownregulatesEGFRlevelsinamutantrenalepithelialcellline,indicatingpotentialbenefitasatreatmentforpolycystickidneydisease.
| CasNo. | 537049-40-4 |
|---|---|
| Purity | ≥96% |
| Formula | C41H43N3O7S |
| FormulaWt. | 721.86 |
| IUPACName | N-[4-[(2R,4R,6S)-4-[(4,5-diphenyl-1,3-oxazol-2-yl)sulfanylmethyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N"-hydroxyoctanediamide |
| Solubility | InDMSO |
| Appearance | whitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | T8000MSDSPDF |
|---|---|
| InfoSheet | T8000InfoSheetPDF |
| Brochures | EpigeneticModifiersBooklet |
LiuW,FanLX,ZhouX,etal.HDAC6regulatesepidermalgrowthfactorreceptor(EGFR)endocytictraffickinganddegradationinrenalepithelialcells.PLoSOne.2012;7(11):e49418.dPMID:23152903.
Aldana-MasangkayGI,Rodriguez-GonzalezA,LinT,etal.Tubacinsuppressesproliferationandinducesapoptosisofacutelymphoblasticleukemiacells.LeukLymphoma.2011Aug;52(8):1544-55.PMID:21699378.
HideshimaT,BradnerJE,WongJ,etal.Small-moleculeinhibitionofproteasomeandaggresomefunctioninducessynergisticantitumoractivityinmultiplemyeloma.ProcNatlAcadSciUSA.2005Jun14;102(24):8567-72.PMID:15937109.
HaggartySJ,KoellerKM,WongJC,etal.Domain-selectivesmall-moleculeinhibitorofhistonedeacetylase6(HDAC6)-mediatedtubulindeacetylation.ProcNatlAcadSciUSA.2003Apr15;100(8):4389-94.PMID:12677000.
