Temozolomideisasecondgenerationimidazotetrazineanticancerchemotherapeuticthatisclinicallyapprovedtotreatgliobastomamultiforme,anaplasticastrocytoma,andoligodendrocytoma.Temozolomideactsasanalkylatingagent,attachingalkylgroupstoguaninebasesinDNAandinterferingwithDNAreplication.Thiscompoundis100%orallybioavailableandentersthecerebrospinalfluideasilyandquickly.
| CasNo. | 85622-93-1 |
|---|---|
| Purity | ≥98% |
| Formula | C6H6N6O2 |
| FormulaWt. | 194.15 |
| ChemicalName | 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide |
| IUPACName | 3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide |
| Synonym | Methazolastone;Temodal;Temodar |
| MeltingPoint | 212°C(dec) |
| Solubility | SolubleinDMSOto39mg/mL,Waterto5mg/mL,Ethanol<1mg> |
| Appearance | Whitetolightpinkpowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | T1849MSDSPDF |
|---|---|
| InfoSheet | T1849InfoSheetPDF |
| Brochures | TemozolomideFlyer |
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