Tenovin-1isaninhibitorofsirtuins1and2(SIRT1/2)thatalsoindirectlyactivatesp53;sirtuinsareconsideredclassIIIhistonedeacetylases(HDACs).Tenovin-1exhibitsanticancerpotential,increasingFOXO3andp53expressionandinducingapoptosisincutaneousT-celllymphomacells.
| CasNo. | 380315-80-0 |
|---|---|
| Purity | ≥98% |
| Formula | C20H23N3O2S |
| FormulaWt. | 369.48 |
| IUPACName | N-[(4-acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide |
| Appearance | WhiteCrystalPowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | T1852InfoSheetPDF |
|---|
NihalM,AhmadN,WoodGS.SIRT1isupregulatedincutaneousT-celllymphoma,anditsinhibitioninducesgrowtharrestandapoptosis.CellCycle.2014Feb15;13(4):632-40.PMID:24343700.
LainS,HollickJJ,CampbellJ,etal.Discovery,invivoactivity,andmechanismofactionofasmall-moleculep53activator.CancerCell.2008May;13(5):454-63.PMID:18455128.
