Tenovin-6isaninhibitorofsirtuins1and2(SIRT1/2)thatalsoindirectlyactivatesp53;sirtuinsareconsideredclassIIIhistonedeacetylases(HDACs).Tenovin-6exhibitsanticancerchemotherapeuticactivityinseveralmodels.Inchroniclymphocyticleukemia(CLL)cells,tenovin-6increaseslevelsofLC3-IIandp62,dysregulatingautophagy.Incoloncancercells,thiscompoundincreaseslevelsofdeathreceptor5(DR5),inducingapoptosis.Tenovin-6alsodecreasestumorgrowthinanimalmodels.
| CasNo. | 1011557-82-6 |
|---|---|
| Purity | ≥98% |
| Formula | C25H34N4O2S |
| FormulaWt. | 454.63 |
| IUPACName | 4-tert-butyl-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide |
| Appearance | Yellowsolid |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | T1853InfoSheetPDF |
|---|
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