Tenoxicam is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, neuroprotective, and antioxidative activities; it inhibits COX-1 and COX-2. Tenoxicam is clinically used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, tendonitis, and bursitis. In neurons, tenoxicam inhibits MPP+-induced decreases in phosphorylated Akt and also scavenges free radicals, preventing lipid peroxidation.
| Cas No. | 59804-37-4 |
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| Purity | ≥98% |
| Formula | C13H11N3O4S2 |
| Formula Wt. | 337.38 |
| Chemical Name | 4-Hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]- 1,2-thiazine-3-carboxamide 1,1-dioxide |
| IUPAC Name | 4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,3-e]thiazine-3-carboxamide |
| Synonym | Alganex; Dolmen; Liman; Mobiflex; Rexalgan; Tilcotil |
| Melting Point | 209-213°C (dec) |
| Solubility | Soluble in DMSO, chloroform and methylene chloride. |
| Appearance | Yellow Crystalline Powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | T1654 Info Sheet PDF |
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Tasaki Y, Yamamoto J, Omura T, et al. Oxicam structure in non-steroidal anti-inflammatory drugs is essential to exhibit Akt-mediated neuroprotection against 1-methyl-4-phenyl pyridinium-induced cytotoxicity. Eur J Pharmacol. 2012 Feb 15;676(1-3):57-63. PMID: 22182582.
Suleyman H, Halici Z, Cadirci E, et al. Indirect role of beta2-adrenergic receptors in the mechanism of anti-inflammatory action of NSAIDS. J Physiol Pharmacol. 2008 Dec;59(4):661-72. PMID: 19212002.
Maffei Facino RM, Carini M, Saibene L. Scavenging of free radicals by tenoxicam: a participating mechanism in the antirheumatic/antiinflammatory efficacy of the drug. Arch Pharm (Weinheim). 1996 Oct;329(10):457-63. PMID: 8933748.
