Thalidomidehaspreviouslybeenclinicallyusedasasedativebutwasfoundtoinducebirthdefectsinpregnantfemales.Recently,thalidomideexhibitsanticancerchemotherapeuticpotentialinthetreatmentofmultiplemyeloma.Additionally,thalidomidedisplaysanti-inflammatoryandimmunomodulatoryactivities,improvingTNBS-inducedcolitisinanimalmodelsbyincreasingexpressionofIL-10anddecreasingexpressionofTNF-αandIL-1β.
| CasNo. | 50-35-1 |
|---|---|
| Purity | ≥98% |
| Formula | C13H10N2O4 |
| FormulaWt. | 258.23 |
| ChemicalName | (±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| IUPACName | 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione |
| Synonym | 1,3-Dioxo-2-(2,6-dioxopiperidin-3-yl)isoindoline;Actimid;Calmore;Distaval;Sedimide;Telagan |
| MeltingPoint | 269-271°C |
| Solubility | Insolubleinwaterandethanol.SolubleinDMSO(56mg/mL). |
| Appearance | WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | T2800InfoSheetPDF |
|---|
LienIC,HorngLY,HsuPL,etal.InternalribosomeentrysiteofbFGFisthetargetofthalidomideforIMiDsdevelopmentinmultiplemyeloma.GenesCancer.2014Mar;5(3-4):127-41.PMID:25053990.
XuJ,ZhengC,HuangY,etal.Efficacyofthalidomideontrinitrobenzenesulfonate-inducedcolitisinyoungratsanditsmechanism.ChinMedJ(Engl).2014;127(12):2368-75.PMID:24931258.
ZhouS,WangF,HsiehTC,etal.Thalidomide-anotorioussedativetoawonderanticancerdrug.CurrMedChem.2013;20(33):4102-8.PMID:23931282.
