Description
Thymopentinisafiveaminoacidpeptidefragmentofthymopoietinthatexhibitsimmunostimulatoryandanticanceractivities.ThymopentindecreasesiNOSactivityinthetreatmentofSezarySyndrome,asevereformoflymphoma.Inleukemiacells,thymopentininhibitsproliferationandcolonyformationandinducesdifferentiation.Inmacrophages,thymopentinincreasespro-inflammatorycytokinesecretion,activationofNF-κB,productionofHSP72,andsignalingbyJNK.Thymopentinshowsclinicalbenefitwhenusedasanadjuvant,improvingtheresponserateinsubjectsadmiNISTeredhepatitisBvaccines.
References
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