Description
ThymoquinoneisaphytochemicalfromNigellasativa(blackcumin)thatexhibitschemopreventive,anticancer,antioxidative,anti-inflammatory,andneuroprotectiveactivities.Inanimalmodelsofbreastcancercarcinogenesis,thymoquinonedecreaseslevelsofmalondialdehydeandlactatedehydrogenaseandsuppressesexpressionofcancer-relatedgenes.Inanimalmodelsofairwayinflammation,thiscompoundpreventsincreasesinlevelsoflymphocytes,monocytes,andneutrophils.Thymoquinonealsopreventsacrylamide-inducedmotordeficienciesanddecreaseslipidperoxidation.Inhepatocellularcarcinomacells,thiscompoundinducesG2phasecellcyclearrestandapoptosis,increaseslevelsofBax,anddecreaseslevelsofVEGFandBcl-2.
References
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