TivantinibisaninhibitorofMETandGSK-3α/βthatexhibitsanticancerchemotherapeuticactivity.Tivantinibinhibitsproliferationofnon-smallcelllungcancer(NSCLC)cellsandiscurrentlyundergoingclinicaltrials,showingimprovementsintimetoprogressionandoverallsurvivalinthetreatmentofhepatocellularcarcinoma.
| CasNo. | 1000873-98-2,905854-02-6 |
|---|---|
| Purity | ≥98% |
| Formula | C23H19N3O2 |
| FormulaWt. | 369.42 |
| Synonym | ARQ-197 |
| Appearance | Lightpinkpowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | T3584InfoSheetPDF |
|---|
RemsingRixLL,KuenziBM,LuoY,etal.GSK3alphaandbetaarenewfunctionallyrelevanttargetsoftivantinibinlungcancercells.ACSChemBiol.2014Feb21;9(2):353-8.PMID:24215125.
RimassaL,PersoneniN,SimonelliM,etal.Tivantinib:anewpromisingmesenchymal-epithelialtransitionfactorinhibitorinthetreatmentofhepatocellularcarcinoma.FutureOncol.2013Feb;9(2):153-65.PMID:23414466.
BagaiR,FanW,MaPC.ARQ-197,anoralsmall-moleculeinhibitorofc-Metforthetreatmentofsolidtumors.IDrugs.2010Jun;13(6):404-14.PMID:20506063.
