Description
Topotecan is an anticancer chemotherapeutic compound that inhibits topoisomerase I and is clinically used to treat various cancers. Topotecan induces apoptosis in retinocytoma cells and ovarian cancer cells.
LKT/TOPOTECAN HYDROCHLORIDE/T5761/5 mg
市场价：
¥1340.00
美元价：
804.00
产品分类：
临床研究
公司分类：
clinical_research
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product ID T5761
Cas No. 119413-54-6
Purity ≥98%
- Description
- Product Info
- Shipping and Storage
- Downloads
- References
Product Info
| Cas No. | 119413-54-6 |
|---|---|
| Purity | ≥98% |
| Formula | C23H25N3O5 • HCl |
| Formula Wt. | 457.91 |
| Chemical Name | (4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9- dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]- quinoline-3,14(4H,12H)-dione hydrochloride |
| Synonym | Hycamtin; NSC-609669; SKF-104864A |
| Melting Point | 213-218°C(dec.) |
| Solubility | Soluble in methanol, water (92 mg/ml at 25 °C), DMSO (92 mg/ml at 25 °C), ethanol (<1 mg/ml="" at="" 25="" °c),="" and="" 1:="" 1="" solution="" of="" dmso:="" pbs="" (ph="" 7.2,="" ~0.5=""> |
| Appearance | Pale Yellow Crystal Powder |
Shipping and Storage
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
Downloads
| MSDS | T5761 MSDS PDF |
|---|---|
| Info Sheet | T5761 Info Sheet PDF |
References
Attia SM, Ahmad SF, Abd-Ellah MF, et al. Germ cell mutagenicity of topoisomerase I inhibitor topotecan detected in the male mouse-dominant lethal study. Food Chem Toxicol. 2013 Dec;62:470-4. PMID: 24036143.
Zhang M, Shan BE, Yuan NF, et al. Effect of topotecan on retinocytoma cell apoptosis and expression of Livin and PTEN. Chin Med J (Engl). 2013 Jan;126(2):340-4. PMID: 23324287.
Caltová K, Cervinka M. Antiproliferative effects of selected chemotherapeutics in human ovarian cancer cell line A2780. Acta Medica (Hradec Kralove). 2012;55(3):116-24. PMID: 23297519.
Sonabend AM, Stuart RM, Yun J, et al. Prolonged intracerebral convection-enhanced delivery of topotecan with a subcutaneously implantable infusion pump. Neuro Oncol. 2011 Aug;13(8):886-893. PMID: 21750007.
品牌介绍
LKT Labs
LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。
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