Description
Toremifeneisaselectiveestrogenreceptormodulator(SERM)thatalsomoderatesandrogenreceptoractivityaswell.Toremifenedisplaysanticancerchemotherapeuticandanti-angiogenicactivities.Clinically,thiscompoundisusedtotreatbreastcancerandprostatecancer.Toremifenedecreasesmicrovesseldensityandinducesremissionofbenignfibrouslesionsinclinicalsettingswithsubjectsexperiencingdesmoidtumors.Additionally,toremifeneincreaseslatencytotumorformation,decreasestumornumber,andincreasessurvivalinanimalmodelsofprostatecancer.
References
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HeidemannJ,OgawaH,OttersonMF,etal.Antiangiogenictreatmentofmesentericdesmoidtumorswithtoremifeneandinterferonalfa-2b:reportoftwocases.DisColonRectum.2004Jan;47(1):118-22.PMID:14719159.
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