Description
Brompheniramineisahalogenatedantihistaminederivativeofpheniraminethatexhibitsanticholinergicandneuromodulatoryactivities.BrompheniramineinhibitstheH1histaminereceptorandalsodisplaysnon-selectiveinhibitionofmuscarinicacetylcholinereceptors(mAChRs).Brompheniramineinhibitshistamine-inducedvasodilationandalsopotentiatestheeffectsofopioidanalgesics.Additionally,brompheniramineistheparentcompoundofzimelidine,aselectiveSEROtoninreuptakeinhibitor(SSRI)thatexhibitsantidepressantactivity;zimelidineinhibitspre-synaptic5-HTreuptakeandmayinhibittheserotonintransporter(SERT)ormonoamineoxidaseB(MAO-B).
References
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