Calcitoningene-relatedpeptideII(CGRPII)exhibitsvasodilatoryandgastrointestinalmodulatoryactivities;italsoappearstobeassociatedwithinflammationindiseasessuchasgoutandrheumatoidarthritis.CGRPIIdilatesarteriolesinvitroandinhibitspentagastrin-stimulatedgastricacidsecretioninclinicalsettings.LikeCGRP,thispeptidelikelybindsRAMP1andCGRPreceptors.
| Purity | ≥95% |
|---|---|
| Formula | C163H265N51O50S2 |
| FormulaWt. | 3803.39 |
| Synonym | CGRPII,rat;β-CGRP,rat |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | C0251InfoSheetPDF |
|---|
VannerS.Mechanismofactionofcapsaicinonsubmucosalarteriolesintheguineapigileum.AmJPhysiol.1993Jul;265(1Pt1):G51-5.PMID:8338172.
HernanzA,DeMiguelE,RomeraN,etal.Calcitoningene-relatedpeptideII,substancePandvasoactiveintestinalpeptideinplasmaandsynovialfluidfrompatientswithinflammatoryjointdisease.BrJRheumatol.1993Jan;32(1):31-5.PMID:7678534.
BeglingerC,BornW,HildebrandP,etal.Calcitoningene-relatedpeptidesIandIIandcalcitonin:distincteffectsongastricacidsecretioninhumans.Gastroenterology.1988Oct;95(4):958-65.PMID:2900791.
