Captoprilisthefirstangiotensin-convertingenzyme(ACE)inhibitormarketed;itisclinicallyusedtotreathypertension,congestiveheartfailure(CHF),anddiabeticnephropathy.Captoprilexhibitsantihypertensive,anti-metastatic,andanticancerchemotherapeuticactivities.Inanimalmodelsoflungcancer,captoprildecreasestumorgrowthandmetastasisandinducescellularapoptosis.
| CasNo. | 62571-86-2 |
|---|---|
| Purity | ≥81% |
| Formula | C9H15NO3S |
| FormulaWt. | 217.29 |
| ChemicalName | N-[(S)-3-Mercapto-2-methylpropionyl]-L-proline |
| IUPACName | (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylicacid |
| Synonym | (2S)-1-(3-Mercapto-2-methylpropionyl)-L-proline;Aceplus;Hypertil;Tensoprel |
| MeltingPoint | 104-108°C |
| Solubility | Solubleinwaterorethanol. |
| Appearance | AWhitetoOff-WhiteCrystallinePowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | C0261MSDSPDF |
|---|---|
| InfoSheet | C0261InfoSheetPDF |
ZidaneF,Zeder-LutzG,AltschuhD,etal.SurfaceplasmonresonanceanalysisofthebindingmechanismofpharmacologicalandpeptidicinhibitorstohumansomaticangiotensinI-convertingenzyme.Biochemistry.2013Dec3;52(48):8722-31.PMID:24168709.
AttoubS,GabenAM,Al-SalamS,etal.Captoprilasapotentialinhibitoroflungtumorgrowthandmetastasis.AnnNYAcadSci.2008Sep;1138:65-72.PMID:18837885.
