Description
Catch-relaxing peptide (CARP) is a peptide originally found in mollusks that exhibits neuromodulatory and cardiomodulatory activity. CARP decreases heart rate and modulates muscle contractility in vivo. Additionally, CARP decreases slowly-inactivating Ca2+ and Ca2+-activated K+ currents in snail neurons.
References
Fujiwara-Sakata M, Kobayashi M. Neuropeptides regulate the cardiac activity of a prosobranch mollusk, Rapana thomasiana. Cell Tissue Res. 1992 Aug;269(2):241-7. PMID: 1423492.
Kiss T. Catch-relaxing peptide (CARP) decreases the Ca-permeability of snail neuronal membrane. Experientia. 1988 Dec 1;44(11-12):998-1000. PMID: 2848713.
Hirata T, Kubota I, Takabatake I, et al. Catch-relaxing peptide isolated from Mytilus pedal ganglia. Brain Res. 1987 Oct 6;422(2):374-6. PMID: 3676797.