CatharanthineisanalkaloidfoundinCatharanthusthatisachemicalprecursorinthesynthesisofvincaalkaloidssuchasvinblastineandvincristine.Catharanthinedisplaysweakanti-mitoticactivity,bindingtubulinpoorly.Catharanthineexhibitsanti-parasitic,vasodilatory,andantihypertensiveactivities.ThiscompoundshowsantimalarialbenefitagainstspeciesofPlasmodium.Invivo,catharanthineinhibitsvoltage-gatedCa2+channelcurrents,decreasingbloodpressureandheartrate.
| Purity | ≥98% |
|---|---|
| Formula | C21H24N2O2•H2SO4 |
| FormulaWt. | 434.51 |
| Appearance | WhitePowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | C0377InfoSheetPDF |
|---|
MuniguntiR,BeckerK,BrunR,etal.DeterminationofantiplasmodialactivityandbindingaffinityofselectednaturalproductstowardsPfTrxRandPfGR.NatProdCommun.2013Aug;8(8):1135-6.PMID:24079187.
JadhavA,LiangW,PapageorgiouPC,etal.Catharanthinedilatessmallmesentericarteriesanddecreasesheartrateandcardiaccontractilitybyinhibitionofvoltage-operatedcalciumchannelsonvascularsmoothmusclecellsandcardiomyocytes.JPharmacolExpTher.2013Jun;345(3):383-92.PMID:23532933.
SertelS,FuY,ZuY,etal.Moleculardockingandpharmacogenomicsofvincaalkaloidsandtheirmonomericprecursors,vindolineandcatharanthine.BiochemPharmacol.2011Mar15;81(6):723-35.PMID:21219884.
